New insight in perivenular lesion formation in multiple sclerosis on weekly susceptibility weighted images
Simon Mure1, Charles Guttmann2, Thomas Grenier1, Hugues Benoit-Cattin1, and François Cotton3
1CREATIS, Villeurbanne cedex, France, 2Center for Neurological Imaging, Brigham and Women's Hospital, Boston, MA, United States, 3CREATIS - HCL, Villeurbanne cedex, France
In this paper, we take advantage of a
unique longitudinal MRI dataset acquired at weekly intervals on untreated
multiple sclerosis patients. We study the signal dynamics of
relapsing-remitting multiple sclerosis lesions on SWI MRI and show, thanks to
an unsupervised spatiotemporal clustering algorithm, that specific signal intensity behaviors exist between the veins and the lesions that are synchronous with
contrast enhancement on gadolinium-enhanced T1-weighted MRI. Our study shows
that vein narrowing depicted on SWI is an early event that appears to precede
blood-brain barrier disruption signified by contrast-enhancement.
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