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Abstract #1290

New insight in perivenular lesion formation in multiple sclerosis on weekly susceptibility weighted images

Simon Mure1, Charles Guttmann2, Thomas Grenier1, Hugues Benoit-Cattin1, and Fran├žois Cotton3

1CREATIS, Villeurbanne cedex, France, 2Center for Neurological Imaging, Brigham and Women's Hospital, Boston, MA, United States, 3CREATIS - HCL, Villeurbanne cedex, France

In this paper, we take advantage of a unique longitudinal MRI dataset acquired at weekly intervals on untreated multiple sclerosis patients. We study the signal dynamics of relapsing-remitting multiple sclerosis lesions on SWI MRI and show, thanks to an unsupervised spatiotemporal clustering algorithm, that specific signal intensity behaviors exist between the veins and the lesions that are synchronous with contrast enhancement on gadolinium-enhanced T1-weighted MRI. Our study shows that vein narrowing depicted on SWI is an early event that appears to precede blood-brain barrier disruption signified by contrast-enhancement.

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