In vivo white matter development of Fmr1 knockout mice
Da Shi1, Jiachen Zhuo1, Su Xu1, Mary C. McKenna2, and Rao P. Gullapalli1
1Diagnostic Radiology, University of Maryland Baltimore, Baltimore, MD, United States, 2Department of Pediatrics, University of Maryland Baltimore, Baltimore, MD, United States
syndrome is the most common genetic cause of autism and is modeled
with the Fmr1 knockout mouse.
investigate recent report of myelination delay in Fragile X,
this study used
translational imaging techniques including T2 mapping and
magnetization transfer imaging to determine myelination changes in
the developing Fmr1 knockout mouse. Age-related trajectory changes in
regional white matter development were observed between the genotypes
and may provide insights into the pathophysiology of Fragile X.
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