Mapping of brain tumor oxygen metabolism in native MRI
Patrick Borchert1, Lasse Dührsen2, Div S. Bolar3, Nils-Ole Schmidt2, Jan-Hendrik Buhk1, Jens Fiehler1, and Jan Sedlacik1
1Neuroradiology, UKE, Hamburg, Germany, 2Neurosurgery, UKE, Hamburg, Germany, 3Martinos Center, MGH, Boston, MA, United States
QUIXOTIC method was tested in conjunction with ASL to map tumor
oxygen metabolism in glioma patients. A higher oxygen extraction
fraction was found for low grade gliomas, whereas lower cerebral
blood flow was found for high grade gliomas. Both parameters were
stable in healthy gray matter. These findings suggest, that the
QUIXOTIC method is able to map tumor oxygen metabolism in conjunction
with ASL. Furthermore, these findings may suggest, that low grade
gliomas may maintain a more aerobic metabolism than high grade
gliomas and that the uncontrolled tumor angiogenesis of high grade
gliomas may cause hindered tumor perfusion.
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