Donna H Murrell1,2, Keng Yeow Tay3, Eugene Wong2,3, Ann F Chambers2,3, Francisco Perera3, and Paula J Foster1,2
1Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3London Health Sciences Centre, London, ON, Canada
Brain
metastatic burden may be underestimated in the clinic because some tumors are
impermeable to Gadolinium (Gd). Preclinical studies by our group demonstrated
that fast imaging employing steady-state acquisition (FIESTA) was advantageous
for detecting small Gd-impermeable tumors. Here, we show clinical translation
of this imaging strategy. We present FIESTA images of human brain metastasis
alongside standard clinical MRI and illustrate potential clinical utility of
this sequence. Initial data suggests FIESTA can visualize intra-tumor
heterogeneity where standard clinical MRI could not. Additional lesions were
observed in FIESTA; we hypothesize some may be arachnoid cysts, though
metastasis cannot be ruled out.
