Abstract #1381

Evaluation of vascular permeability in gliomas by using parameter K2 from dynamic susceptibility contrast data-sets and histogram analysis.

Toshiaki Taoka¹, Hisashi Kawai¹, Toshiki Nakane¹, Toshiteru Miyasaka², and Shinji Naganawa¹

¹Radiology, Nagoya University, Nagoya, Japan, ²Radiology, Nara Medical University, Kashihara, Japan

Permeability images can provide additional information to perfusion images in the clinical practice of brain tumors. However, permeability imaging by dynamic contrast enhancement methods requires a long acquisition time. K2 is an index that represents permeability and can be calculated from the dataset of perfusion images with the dynamic susceptibility contrast method, which requires a short acquisition time. In the current study, we calculated K2 for various grades of gliomas and found that K2 showed a significantly higher 20th percentile value in Grade IV compared to Grade III gliomas, providing useful information for grading of gliomas.

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