Abstract #1393

Disrupted reward circuits is associated with cognitive deficits, depression severity, and trait property in unmedicated major depressive disorder

Liang Gong¹, Yingying Yin¹, Cancan He¹, Chunming Xie¹, Yonggui Yuan¹, Zhijun Zhang¹, and Hongxing Zhang²

¹Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China, People's Republic of, ²Department of Psychiatry, Henan Provincial Mental Hospital, XingXiang, China, People's Republic of

we employed the resting-state fMRI technique with voxelwise multivariate regression analysis to identify that the disrupted topological organization within reward circuits was significantly associated with cognitive deficits, depression severity, and trait property in major depressive disorder (MDD) patients. Importantly, distinct and common neural pathways underlying cognitive deficit and depression were identified, and implied the independent and synergistic effects of cognitive deficits and depression severity on reward circuits in MDD patients.

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