Abstract #1408

Deformation-based morphometry identifies brain structural damages in 6 month-old infants with neonatal encephalopathy and predicts their developmental outcome

Hosung Kim¹, Kevin Shapiro², Maria Luisa Mandelli², Hannah Clanley Glass², Dawn Gano², ELIZABETH Rogers³, Donna M Ferriero², Anthony James Barkovich¹, and Duan Xu¹

¹Radiology & Biomedical Imaging, University california San francisco, San Francisco, CA, United States, ²Neurology, University california San francisco, San Francisco, CA, United States, ³Pediatrics, University california San francisco, San Francisco, CA, United States

Neonatal encephalopathy (NE) is a major cause of mortality and permanent neurological disabilities in term infants. Using t1w MRI and DBM, we found that neonatal seizure was related to WM atrophy in multiple locations. Larger birth weight was associated with increased overall GM and WM volumes. A significant association was identified between language ability at 2 years old and increase in GM volume in Wernicke’s area. This DBM approach has the potential for predicting early developmental outcome in infants with NE, as the volume of Wernicke’s area significantly correlated with the scores of language ability evaluated in early childhood.

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