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Abstract #1412

Maternal Obesity Affects Offspring’s Brain Resting-State Functional Connectivity

Xuehua Li1,2, Yilu Zhang2, Aline Andres1, R.T. Pivik1, Charles Glasier2, Raghu Ramakrishnaiah2, Thomas Badger1, and Xiawei Ou1,2,3

1Arkansas Children's Nutrition Center, Little Rock, AR, United States, 2Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, United States, 3Arkansas Children's Hospital Research Institute, Little Rock, AR, United States

Recent studies have reported negative associations between maternal obesity during pregnancy and cognitive/neurodevelopmental outcome of children. It is speculated that neuro-programming differs in offspring of obese and normal weight women. In this study, we evaluated and compared the resting-state functional connectivity in 2-week-old infants born to normal weight or obese mothers, and we observed significant differences in brain connectivity associated with maternal obesity.

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