Abstract #1430

Early extravasation of the experimental contrast agent GadoflurineM in ischemic stroke predicts infarct severity

Angelika Hoffmann¹, Xavier Helluy¹, Tassilo Dege¹, Reiner Kunze², Hugo Marti², Sabine Heiland¹, Martin Bendszus¹, and Mirko Pham¹

¹Neuroradiology, University of Heidelberg, Heidelberg, Germany, ²Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany

Very early post ischemic blood-brain barrier disruption has been difficult to detect in vivo. In this study we show that the experimental contrast agent Gadofluorine M visualizes very early blood-brain barrier disruption in a mouse model of ischemic stroke at 9.4T. Contrast agent leakage occurs multifocally along cortical and subcortical microvessels. The degree of leakage predicts final infarct severity and could therefore serve as a new predictive marker in ischemic stroke.

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