Magnetic Resonance Imaging Detection of Multiple Ischemic Injury Produced by a Mild Transient Cerebral Ischemia Preceded by an Experimental Minor Stroke
Ursula I. Tuor1,2, Min Qiao1, David Rushforth2, and Tadeusz Foniok2
1Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada, 2Experimental Imaging Centre, University of Calgary, Calgary, AB, Canada
A mild photothrombosis elicited
an initial ischemic insult consisting of a small cortical infarct overlying a
peri-infarct region of scattered necrosis.
One, 2 or 7 days later a relatively short transient middle cerebral
artery occlusion was produced. Peri-infarct
regions were observed to be susceptible to the second (1 or 2 day later) ischemic
event appearing as enhanced T2 increases and increased tissue damage. With one week between insults, there was no T2
increase and less ischemic damage in the peri-infarct region. The results are
relevant for improving diagnosis and management of patients with recurrent
transient ischemic insults.
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