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Abstract #1472

Contrast Enhanced MRI Reveals Perplexing T2 effect of Aggregate Forming Compounds In the Murine Placenta

Marina Lysenko1, Noam Ben-Eliezer1, Inbal E Biton2, Joel R Garbow3, and Michal Neeman1

1Biological Regulation, Weizmann Institute of Science, Rehovot, Israel, 2Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel, 3Biomedical Magnetic Resonance Laboratory, Mallinckrodt Institute of Radiology, Washington University, St. Louis, MO, United States

The murine placenta is a complex organ, consisting of different cell compartments that greatly influence its blood-flow pattern. Dynamic contrast enhanced (DCE) MRI of murine placental perfusion has been reported previously using both low and high MW contrast media. In this study, we used high-MW, albumin-based macromolecular contrast agent that does not cross the placental barrier, but, instead, forms contrast-based aggregates that accumulate in the maternal vasculature simultaneously with active contrast internalization by trophoblast cells in the labyrinth .To interpret the observed data, we suggest a novel model for describing feto-maternal processing and aggregate formation of labeled albumin in placental DCE-MRI experiments.

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