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Abstract #1486

Whole brain volumetric perfusion imaging with high spatial resolution using simultaneous multi-slab (SMSB) 3D GRASE pCASL

Yi Wang1, Xingfeng Shao1, Steen Moeller2, and Danny JJ Wang1

1Neurology, UCLA, Los Angeles, CA, United States, 2Center of Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

The temporal SNR of simultaneous multi-slice (SMS) 2D EPI ASL has been shown to be inferior to that of 3D background suppressed GRASE. In this work, we present a novel simultaneous multi-slab (SMSB) 3D GRASE sequence for volumetric pCASL imaging with high spatial resolution. The image quality of SMSB-GRASE was evaluated and compared to a standard 3D GRASE pCASL sequence. Preliminary results demonstrated the feasibility for whole-brain volumetric perfusion imaging at a high spatial resolution, although the drop in RF slice profiles in the overlapped boundary slices still needs to be addressed in future work.

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