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Abstract #1502

Measurement of the Resonance Frequency of Macromolecular Protons in Brain

Xu Jiang1,2, Peter van Gelderen1, and Jeff H. Duyn1

1AMRI, LFMI, NINDS, NIH, Bethesda, MD, United States, 2Physics, University of Maryland, College Park, MD, United States

Studying the spectral asymmetry in Magnetization Transfer (MT) is essential for precise estimation of MT-related parameters from off-resonance MT experiments. Measurement of the delay-dependent water proton saturation following composite MT pulses was used to determine parameters for a 2-pool exchange model. These parameters were further used to calculate saturation levels of macromolecular protons (MPs) following off-resonance MT pulses. The off-resonance frequency for MPs is found to be -2.7ppm from water for fixed marmoset brain, and -2.56ppm for human brain. This is consistent with previous studies.

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