3D Clinical APTw MRI with Improved Contrast Homogeneity
Jochen Keupp1, Jinyuan Zhou2, and Osamu Togao3
1Philips Research, Hamburg, Germany, 2Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 3Clinical Radiology, Kyushu University Hospital, Fukuoka, Japan
APTw MRI is an emerging technique for sensitive tissue characterization, in particular in oncology (e.g. tumor grading). Fast-spin-echo(FSE)-Dixon acquisition techniques allow efficient and simultaneous acquisition of APT weighted (APTw) and ΔB0 information. An improved FSE-Dixon APTw acquisition protocol with intrinsic ΔB0 correction was implemented on a clinical MRI scanner, using multiple averages with saturation at the amide chemical shift (Δω=+3.5ppm). Contrast homogeneity was evaluated in a volunteer study and is presented together with initial clinical results on brain tumor patients.
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