Chemical exchange-sensitive spin-lock MRI of glucose and deoxyglucose in brain tumors
Tao Jin1, Bistra Iordanova1, Ping Wang1, and Seong-Gi Kim2,3
1University of Pittsburgh, Pittsburgh, PA, United States, 22Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, 3Department of Biomedical Engineering, Sungkyunkwan University, Kuwon, Korea, Republic of
Glucose uptake and metabolism are important
biomarkers for tumor diagnosis and prognosis. Recent studies showed that the
glucose uptake and metabolism can be measured by a chemical exchange sensitive
spin-lock (CESL) MRI approach with administration of non-labelled glucose or
analogs (glucoCESL), providing unique advantage over the widely used position
emission tomography technique. In this preliminary study, we evaluated the
efficacy of glucoCESL for the study of brain tumor. The sensitivity and
spatiotemporal characteristics of CESL signal with administration of D-Glucose, 2-deoxy-D-glucose and
L-glucose were compared.
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