Meeting Banner
Abstract #1521

Influence of tissue integrity and external field strength on the exchange-relayed NOE-CEST effect of mobile proteins

Johannes Windschuh1, Moritz Zaiss1, Jan-Eric Meissner1, Steffen Goerke1, and Peter Bachert1

1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

We investigated the dependencies of the exchange-relayed Nuclear Overhouser Effect (rNOE) observable in Chemical Exchange Saturation Transfer (CEST) experiments on tissue integrity and static magnetic field strength B0. By comparison of a homogenized and native sample of white matter tissue of animal brain we could show that the CEST signal of the aliphatic rNOE is independent of tissue structure. The observed increase of all CEST effects on decrease of B0 probably results from relatively broader saturation bandwidth at lower field strengths. No indication for a rNOE dependency on B0 differing from that of chemical exchange effects could be found.

This abstract and the presentation materials are available to members only; a login is required.

Join Here