Abstract #1536

Fast and Accurate T2 Mapping from Multi Spin Echo Data Using Bloch-Simulation-Based Reconstruction: Investigation of intra-subject and inter-scan stability and reproducibility

Veronica Cosi¹, Akio Ernesto Yoshimoto², Timothy Shepherd^2,3, KAI Tobias Block^2,3, Daniel K Sodickson^2,3, and Noam Ben-Eliezer^2,3

¹Department of Specialised, Experimental, and Diagnostic Medicine, University of Bologna, Bologna, Italy, ²Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, ³Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States

Accurate quantification of T₂ values in vivo poses a long-standing challenge, hampered by the inherent bias of fast multi-SE protocols by stimulated and indirect echoes, non-rectangular slice profile and transmit-field inhomogeneities. This bias, moreover, is dependent on the sequence implementation and parameter-set employed, and thus varies between scanners and vendors. We present full stability and reproducibility tests of a recently developed T₂ mapping technique – the echo-modulation curve (EMC) algorithm – which uses precise Bloch simulations of the pulse-sequence scheme to deliver the true T₂ value of the tissue in a manner that is independent of the parameter-set and scanner being used.

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