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Abstract #1578

Quantitative susceptibility mapping of kidney injury in a model of ischemia reperfusion

Luke Xie1, Vivian S. Lee2, Hongjiang Wei3, Yi Qi4, Susan B. Gurley5, G. Allan Johnson4, and Chunlei Liu3

1Radiology, University of Utah, Salt Lake City, UT, United States, 2Utah Center for Advanced Imaging Research, Radiology, University of Utah, Salt Lake City, UT, United States, 3Brain Imaging Analysis Center, Radiology, Duke University Medical Center, Durham, NC, United States, 4Center for In Vivo Microscopy, Radiology, Duke University Medical Center, Durham, NC, United States, 5Medicine-Nephrology, Duke University Medical Center, Durham, NC, United States

BOLD MRI via T2* mapping can detect changes in kidney injuries. However, BOLD MRI can be insensitive and the source of signal change is not clear. Quantitative susceptibility mapping (QSM) is very sensitive to molecular composition and can identify sources as paramagnetic, such as deoxygenated hemoglobin. In this study, we applied QSM to characterize the source of signal change and compared it with BOLD T2* maps. We used a model of ischemia reperfusion in mouse kidneys and imaged at 1 hr, 1 day, 7 days, and 14 days after injury.

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