Abstract #1581

Assessing fibrotic damage to renal structure and function with T2-weighted and ASL MRI

Christopher Charles Conlin^1,2, Yangyang Zhao², Yufeng Huang³, and Jeff Lei Zhang^1,4

¹Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States, ²Bioengineering, University of Utah, Salt Lake City, UT, United States, ³Nephrology, University of Utah School of Medicine, Salt Lake City, UT, United States, ⁴Radiology, University of Utah School of Medicine, Salt Lake City, UT, United States

This study examined the suitability of T2 and ASL-measured renal perfusion as biomarkers for fibrotic kidney disease. Renal perfusion was measured in healthy and fibrotic rats using a multi-TI ASL protocol and compared to renal T2 as well as urinary and histological fibrosis markers. Significantly reduced renal perfusion was observed in fibrotic rats, in parallel with increased renal T2, proteinuria, and mesangial matrix in the glomerular tuft. The sensitivity of T2 and perfusion to fibrotic kidney damage suggests that ASL and T2-weighted MRI may provide improved assessment of renal fibrosis and prove useful for the early detection of renal disease.

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