Abstract #1612

T1 relaxation time in lungs of asymptomatic smokers

Daniel Alamidi¹, Simon Kindvall², Penny Hubbard Cristinacce³, Deirdre McGrath³, Simon Young⁴, Josephine Naish³, John Waterton³, Per Wollmer⁵, Sandra Diaz⁵, Marita Olsson⁶, Paul Hockings^7,8, Kerstin Lagerstrand¹, Geoffrey Parker^3,9, and Lars E Olsson²

¹Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, ²Department of Medical Physics, Lund University, Translational Sciences, Malmö, Sweden, ³Centre for Imaging Sciences and Biomedical Imaging Institute, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom, ⁴AstraZeneca R&D, Alderley Park, United Kingdom, ⁵Department of Translational Medicine, Lund University, Malmö, Sweden, ⁶AstraZeneca R&D, Mölndal, Sweden, ⁷Medtech West, Chalmers University of Technology, Gothenburg, Sweden, ⁸Antaros Medical, BioVenture Hub, Mölndal, Sweden, ⁹Bioxydyn Ltd, Manchester, United Kingdom

Tobacco smoking is the primary cause of COPD. MRI may improve the characterization of COPD where T1 of the lungs is a potential biomarker. We investigated whether smoking affects lung T1 in individuals with no known lung disease. Lung T1 measurements were performed in asymptomatic current and never smokers. T1 was shortened with age and an indication of shortened T1 in smokers was observed that most likely reflects early signs of smoking-induced lung pathology. Our results may be of utility to power future prospective studies with larger cohorts and improved regional analysis.

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