Abstract #1621

Hyperpolarized Xenon-129 Lung 3D SB-CSI at 1.5 and 3 Tesla

Steven Guan¹, Kun Qing¹, Talissa Altes¹, John Mugler III¹, Borna Mehrad¹, Michael Shim¹, Quan Chen¹, Paul Read¹, James Larner¹, Iulian Ruset^2,3, Grady Miller¹, James Brookeman¹, William Hersman^2,3, and Jaime Mata¹

¹University of Virginia, Charlottesville, VA, United States, ²University of New Hampshire, Duhram, NH, United States, ³XeMed, Duhram, NH, United States

3D Single-Breath Chemical Shift Imaging (3D SB-CSI) is capable of non-invasively assessing regional lung ventilation and gas uptake/exchange within a single breath-hold, typically less than 13 seconds. From this study, we present preliminary clinical results of 3D SB-CSI from healthy, cystic fibrosis (CF), interstitial lung disease (ILD), and lung cancer (LC) subjects at 1.5T and 3T. Having novel information on regional changes in ventilation and gas uptake/exchange allows for a better understanding of lung physiology, disease progression, and treatment efficacy.

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