Abstract #1672

Similarity in structural and functional network connectivity evolution over duration of TLE

Victoria L. Morgan¹, Ahmet Cakir², Benjamin N. Conrad¹, Bassel Abou-Khalil³, Adam W. Anderson^1,4, Zhaohua Ding¹, and Bennett A. Landman^1,2

¹Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ²Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States, ³Neurology, Vanderbilt University, Nashville, TN, United States, ⁴Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Temporal lobe epilepsy (TLE) is a common and relatively homogeneous form of epilepsy in which seizures originate in the mesial temporal regions including the hippocampus and propagate across the brain. This work represents the first step in characterizing the functional (FC) structural (SC) network connectivity evolution in TLE using MRI. We found consistent decreases in ipsilateral hippocampus and insula FC and SC primarily after 10 years of duration of disease in patients with seizure freedom after surgery. In those with seizure recurrence, there were more severe bilateral hippocampal SC decreases when compared to those with seizure freedom.

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