Abstract #1743

Calibration, validation, and sensitivity analysis of a 3D method for the mapping of brain venous oxygenation

Deng Mao^1,2, Yang Li¹, Peiying Liu¹, Shin-Lei Peng³, and Hanzhang Lu¹

¹Russell H. Morgan Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ²Graduate School of Biomedical Sciences, Univ of Texas Southwestern Medical Center, Dallas, TX, United States, ³Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan

The present study aimed to further develop and investigate of a non-invasive, efficient and reproducible technique to map brain venous oxygenation in 3D. We first improved the processing pipeline by substracting angiogram to remove arterial content and apply threholdings to eliminate poor fitted and low signal voxels. We then calibrated T2* to oxygenation relationship in vitro using the same technique. In addition, we used hyperoxia challenge to test its sensitivity and combined TRUST MRI method for validation.

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