Abstract #1752

Quantitative vascular imaging with QUTE-CE MRI

Codi Gharagouzloo¹, Ju Qiao², Liam Timms³, Aniket Pandya³, Praveen Kulkarni⁴, Craig Ferris⁵, and Srinivas Sridhar³

¹Bioengineering, Northeastern University, Boston, MA, United States, ²Industrial Engineering, Northeastern University, Boston, MA, United States, ³Physics, Northeastern University, Boston, MA, United States, ⁴Northeastern University, Boston, MA, United States, ⁵Center for Translational Neuroimaging (CTNI), Northeastern University, Boston, MA, United States

We demonstrate a unique type of vascular imaging using ferumoxytol as an iron-oxide nanoparticle contrast agent (CA) and a 3D ultra-short TE (UTE) pulse sequence. The raw UTE signal intensity is shown to be quantitative by comparison to excised blood immediately after imaging with n=5 Sprague Dawley rats. In this preliminary study, we calculate the cerebral blood volume (CBV) on a regional basis using a 174-region anatomic atlas that is consistent among animals and is independent of CA concentration.

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