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Abstract #1905

Toward a voxel-based analysis (VBA) of quantitative magnetic susceptibility maps (QSM): Strategies for creating brain susceptibility templates

Jannis Hanspach1, Michael G Dwyer1, Niels P Bergsland1,2, Xiang Feng3, Jesper Hagemeier1, Paul Polak1, Nicola Bertolino1, J├╝rgen R Reichenbach3,4, Robert Zivadinov1,5, and Ferdinand Schweser1,5

1Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, 2MR Research Laboratory, IRCCS Don Gnocchi Foundation ONLUS, Milan, Italy, 3Medical Physics Group, Department of Diagnostic and Interventional Radiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, 4Michael Stifel Center for Data-driven and Simulation Science Jena, Friedrich Schiller University Jena, Jena, Germany, 5MRI Molecular and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States

Quantitative susceptibility mapping (QSM) is a recent in vivo magnetic resonance imaging (MRI) technique that provides quantitative information about the bulk magnetic susceptibility distribution in tissues, a promising measure for studying brain iron. A voxel-based analysis (VBA) of susceptibility maps would facilitate a better understanding of the intricate anatomical structure (e.g. sub-nuclear regions) of deep gray matter and its relation to diseases and normal aging.

In the present work, we developed and quantitatively assessed six strategies for creating a susceptibility brain template for VBA based on ANTs, representing the first step toward an understanding of sub-nuclear susceptibility changes without the need for a priori information.

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