1Biomedical Engineering Program, University of Calgary, Calgary, AB, Canada, 2Departments of Radiology and Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
MRI is routinely collected in patient care but is limited in assessing changes
in tissue microstructure. We developed a new method to assess tissue
directionality using the power spectrum of T2-weighted MRI and validated it
using the highly coherent structure, corpus callosum. In controls, power
spectrum-derived angles corresponded exactly with the predicted aligning
directions of the corpus callosum, and such aligning patterns were interrupted
in advanced MS patients with increased variability and angular entropy.
Fourier-based power spectrum may provide advanced measures of tissue
directionality following myelin and axonal pathology using clinical scans.