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Abstract #1931

Identification of Microbleeds on Postmortem Brain of Normal Aging Elderly and Dementia Patients

Shunshan Li1, Lily Zhou2, Mark J Fisher3, Ronald C Kim4, Vitaly Vasilevko5, David Cribbs5, Annlia Hill3, and Min-Ying Su6

1Tu & Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, university of california, irvine, irvine, CA, United States, 2Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, People's Republic of, 3Department of Neurology, University of California, Irvine, Irvine, CA, United States, 4Department of Pathology, University of California, Irvine, Irvine, CA, United States, 5Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, irvine, CA, United States, 6Tu & Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, irvine, CA, United States

The postmortem brain MR images include air-bubble artifacts and typical microbleeds(MBs) are less than 200 ┬Ám which make MBs detection very challenging. In this project we developed an optimization MR imaging method to detect possible MBs on postmortem brains of patients with and without dementia, hoping to provide information to guide neuropathological examination to sample the suspicious MBs areas, and improve the chance of identifying true MBs to better understand its role in normal aging and development/progression of dementia, and further develop streamlined automatic MBs detection software.

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