Abstract #1931

Identification of Microbleeds on Postmortem Brain of Normal Aging Elderly and Dementia Patients

Shunshan Li¹, Lily Zhou², Mark J Fisher³, Ronald C Kim⁴, Vitaly Vasilevko⁵, David Cribbs⁵, Annlia Hill³, and Min-Ying Su⁶

¹Tu & Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, university of california, irvine, irvine, CA, United States, ²Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, People's Republic of, ³Department of Neurology, University of California, Irvine, Irvine, CA, United States, ⁴Department of Pathology, University of California, Irvine, Irvine, CA, United States, ⁵Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, irvine, CA, United States, ⁶Tu & Yuen Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, irvine, CA, United States

The postmortem brain MR images include air-bubble artifacts and typical microbleeds(MBs) are less than 200 µm which make MBs detection very challenging. In this project we developed an optimization MR imaging method to detect possible MBs on postmortem brains of patients with and without dementia, hoping to provide information to guide neuropathological examination to sample the suspicious MBs areas, and improve the chance of identifying true MBs to better understand its role in normal aging and development/progression of dementia, and further develop streamlined automatic MBs detection software.

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