Purpose: Determine the accuracy of MATCH in the characterization of plaque composition in patients in comparison with the conventional multi-contrast approach, using histopathology as the gold standard.
Methods: Twenty-two patients scheduled for carotid endarterectomy underwent preoperative carotid MRI with MATCH and the conventional protocol, blinded image review for composition identification was performed by 2 radiologists. Carotid histopathological specimens stained with HE and Masson, matched with this two protocol images, Cohen kappa (K) was computed to quantify the agreement in the detection of components among this two protocols and histopathology.
Results: Moderate to good agreement was seen between histopathological specimens and multi-contrast protocol in the detection of plaque components (IH k=0.704 , CA k=0.763, LR/NC k=0.844). Similar results were seen between histopathological specimens and MATCH (IH k=0.703CA k=0.740, LR/NC k=0.850).