The Influence of Bolus Arrival Time in Pharmacokinetic Analysis of Dynamic Contrast-Enhanced MRI of Breast Masses
Endre Grøvik1,2, Atle Bjørnerud1,2, Tryggve Holck Storås1, Kjell-Inge Gjesdal3, and Kathinka Dæhli Kurz4
1The Intervention Centre, Oslo University Hospital, Oslo, Norway, 2Department of Physics, University of Oslo, Oslo, Norway, 3Sunnmøre MR klinikk AS, Ålesund, Norway, 4Department of Radiology, Stavanger University Hospital, Stavanger, Norway
The purpose was
to evaluate the influence of BAT in pharmacokinetic analysis of breast masses,
by estimating the kinetic parameters both with and without BAT-delay correction. Thirty-nine
verified breast masses were examined using a high temporal resolution EPI
sequence. The image-data were analyzed using a two-compartment
kinetic model with and without BAT-delay correction. The relationship between
the relative parametric error and BAT-delay were investigated. The result indicates that neglecting the delayed BAT leads
to an overestimation of Ktrans, kep, and, ve, and a underestimation of vp, and that the
delayed BAT needs to be accounted for in the model-based analysis.
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