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Abstract #1964

Application of the inhomogeneous variable flip angle (I-VFA) scheme in hyperpolarized 129Xe DWI

Jianping Zhong1,2, Weiwei Ruan1, Xianping Sun1, Chaohui Ye1,2, and Xin Zhou1

1State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Chinese Acad Sci, Wuhan, China, People's Republic of, 2School of Physics, Huazhong University of Science and Technology, Wuhan, China, People's Republic of

SNR and resolution are two important parameters for the quantitative assessment of MR images. In k-space, the central part contributes SNR, whereas the edges contribute details. The accuracy of the apparent diffusion coefficient (ADC) calibration was significantly affected by SNR. For hyperpolarized GRE sequences, the homogeneous variable flip angle scheme is sub-optimal and leads to low SNR images. We propose a simple method termed inhomogeneous variable flip angle (I-VFA) to derive ADC of hyperpolarized gases. Higher SNR images and more stable results can be achieved by this simple method.

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