Abstract #1968

Diffusion Kurtosis Imaging and Tensor Imaging for Evaluation of Renal Changes in Diabetic Nephropathy: Preliminary study

Fan Mao¹, Lihua Chen¹, Yu Zhang², Tao Ren¹, Chenglong Wen¹, and Wen Shen¹

¹Tianjin First Center Hospital, Tianjin, China, People's Republic of, ²Philips healthcare, Beijing, China, People's Republic of

Diffusion Tensor Imaging (DTI) as a noninvasive technique can provide valuable information based on the Brownian motion of water. However, the diffusion of water molecules in biological tissue like kidney does not follow a Gaussian distribution. Diffusion Kurtosis Imaging (DKI) can reflect the degree of restriction of hydrogen diffusion movement, and might detect the diffusion changes of kidney diseases more sensitive than DTI. Our study compared diffusion changes of DKI with DTI in kidneys of DN and healthy controls. The result showed DKI can be used for detecting renal changes in diabetes nephropathy with higher sensitivity compared to DTI.

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