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Abstract #1993

Numerical Simulations Comparing Pore Imaging Methods Based on Diffusion-Weighted MR Imaging

Yasar Goedecke1 and J├╝rgen Finsterbusch1

1Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

In a conventional diffusion-weighted MRI experiment, the signal amplitude depends on the squared magnitude of the Fourier transformation of the pore or cell geometry, i.e. the underlying cell or pore geometry cannot be reconstructed. Several approaches have been proposed that determine the otherwise missing phase information and, thus, can image the pore or cell geometry directly. Here, the performance of these methods is compared with respect to their applicability in practice, e.g. considering the impact of the noise level, mixtures of pore sizes, orientations, and shapes, and gradient pulse durations and diffusion times achievable on standard MRI systems.

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