Abstract #2006

Does Myelin Water Influence DWI?

Kevin D Harkins¹ and Mark D Does^1,2,3,4

¹Institute of Image Science, Vanderbilt University, Nashville, TN, United States, ²Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ³Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, ⁴Electrical Engineering, Vanderbilt University, Nashville, TN, United States

The presence and movement of myelin water is often neglected from models of DWI signal. This study presents a Monte Carlo simulation illustrating that myelin water diffusion can have a subtle but important impact on measured D_app and K_app values, and that incorporating myelin water diffusion can influence myelin-content dependent changes in D_app and K_app.

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