Jonathan I Sperl1, Ek Tsoon Tan2, Miguel Molina Romero1,3, Marion I Menzel1, Chris J Hardy2, Luca Marinelli2, and Thomas K.F. Foo2
1GE Global Research, GARCHING, Germany, 2GE Global Research, NISKAYUNA, NY, United States, 3Institute of Medical Engineering, Technische Universität München, GARCHING, Germany
The measurement of axonal diameter by diffusion
MRI techniques has assumed major interest in the research community. While most
work has focused on developing and comparing various multi-compartment models,
only minor efforts have been undertaken to optimize corresponding acquisition
protocols. In this work we perform simulations using a rather simple two-compartment
model, but study the effect of various choices of acquisition parameters on the
precision and the bias of the fitted parameters. More precisely, we analyze
potential sampling strategies in the 2D design space spanned by the two timing parameters
(Δ, δ) of the diffusion encoding.
