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Abstract #2018

Maximum b-value dependence of Diffusion kurtosis imaging sensitivity in detecting white matter microstructure

Miao Sha1, Yuanyuan Chen1, Xin Zhao1, Man Sun2, Weiwei Wang1, Hongyan Ni2, and Dong Ming1

1Tianjin University, Tianjin, China, People's Republic of, 2Tianjin First Center Hospital, Tianjin, China, People's Republic of

Diffusion kurtosis imaging is a powerful technique to measure the non-gaussion diffusion as well as the complicated microstructure. In this paper, we conducted a comparison between different acquisitions with different maximum b-value on normal volunteers. We found that the outcome of diffusion kurtosis imaging was influenced by the maximum b-value in the acquisition. And this influence was highly associated with the microstructure, including both radial profile and angular profile in the structure reconstruction, which indicated the mechanism of non-gaussion under high b-value.

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