Abstract #2027

Modelling radial and tangential fibres in the neocortex

Luke J. Edwards¹, Siawoosh Mohammadi^1,2, Pierre-Louis Bazin³, Michiel Kleinnijenhuis⁴, Kerrin J. Pine¹, Anne-Marie van Cappellen van Walsum⁵, Hui Zhang⁶, and Nikolaus Weiskopf^1,3

¹Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, UCL, London, United Kingdom, ²Institut für Systemische Neurowissenschaften, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, ³Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁴FMRIB Centre, University of Oxford, Oxford, United Kingdom, ⁵Department of Anatomy, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands, ⁶Centre for Medical Image Computing, Department of Computer Science, UCL, London, United Kingdom

The structure of neocortical grey matter is complex due to the crossing intracortical neuronal connections involved in cortical processing. Herein we present a two-step method to capture radial and tangential fibre structure of neocortex from diffusion data: first the radial cortical orientation is extracted voxelwise using surface-based methods, and then a three-compartment diffusion model extracts radial and tangential fibre volume fractions. We demonstrate in a post mortem sample of human V1 tissue that this method captures structure known from histology and comparable diffusion models, implying potential future use as a probe of intracortical neuronal connectivity.

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