Yasuhiko Tachibana1,2, Takayuki Obata1,2, Hiroki Tsuchiya1, Tokuhiko Omatsu1,2, Riwa Kishimoto1,2, Thorsten Feiweier3, and Hiroshi Tsuji1
1Research Center of Charged Particle Therapy, National Institute of Radiological Science, Chiba, Japan, 2Applied MRI Research, National Institute of Radiological Science, Chiba, Japan, 3Siemens Healthcare GmbH, Erlangen, Germany
We performed multi-b and
multi-diffusion-time DWI (MbMdt-DWI) on human brain to visualize the mixture of
restricted and hindered diffusion components, and also the water exchange
between them. The diffusion parameters including the exchange time were
calculated. The observed signal patterns clearly indicated the existence of the
inter-compartmental water exchange. The calculated exchange time was within the
appropriate range assumed from a previous cell-based study in vitro. MbMdt-DWI may be useful for assessing micro-diffusion in
human brain.
