White matter microstructural deficits in schizophrenia using generalized kurtosis
Arash Nazeri1, Lipeng Ning2, Jon Pipitone1, David J. Rotenberg1, Yogesh Rathi2, and Aristotle N. Voineskos1
1Research Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada, 2Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
Numerous
studies have used diffusion tensor imaging to investigate
schizophrenia-related white matter microstructural deficits. Diffusion tensor imaging assumes a
Gaussian distribution for the water molecule displacement. However, this
assumption may not be valid in the complex biological tissues such as white
matter. Using directional radial basis function it is possible to
estimate ensemble average diffusion propagator and generalized
kurtosis of water diffusion (a measure of non-Gaussianity). Our results suggest that white matter generalized kurtosis is more
sensitive to differences between persons with schizophrenia and healthy
controls than diffusion tensor model parameters (particularly in frontotemporal
superficial white matter areas).
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