Iron-based T1 MRI contrast agent for MR-guided drug delivery from temperature sensitive liposomes
Esther Kneepkens1, Adriana Fernandes2, Klaas Nicolay3, and Holger Grüll3,4
1Biomedical NMR, Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2Universidade de Lisboa, Lisbon, Portugal, 3Eindhoven University of Technology, Eindhoven, Netherlands, 4Philips Research, Eindhoven, Netherlands
The aim of this study was to investigate the potential
of Fe(III) N-succinyl deferoxamine (Fe-SDFO) as a safe T1 contrast
agent for encapsulation in temperature
sensitive liposomes (TSLs) in order to visualize drug release from TSLs when
using Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU). Two TSLs were developed that contained either
Fe-SDFO or doxorubicin. Both TSLs showed suitable release and stability
characteristics in vitro. An in
vivo proof-of-concept study was carried out in tumor-bearing rats treated
with MR-HIFU. Treated tumors showed an increase in R1 and future
work aims to correlate the R1 change with tumor drug
concentrations.
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