Abstract #2206

Feasibility of Non-invasive Proton-Density Fat Fraction Evaluation using a Single-sided MR device

Vanessa L. Landes¹, Eamon K. Doyle^1,2, Pablo J. Prado³, John C. Wood^1,2, and Krishna S. Nayak⁴

¹Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ²Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ³One Resonance, LLC, San Diego, CA, United States, ⁴Electrical Engineering, University of Southern California, Los Angeles, CA, United States

We investigate the use of a magnet with flat field isosurfaces over 4 cm for assessment of proton density fat fraction (PDFF). We experimentally demonstrate a correlation between PDFF and apparent T2 in phantoms. Apparent T2 measurement variability is low enough to produce invertible curves of T2 vs. PDFF in intervals of 2% PDFF for a 0 – 17% PDFF range at 0ºC and intervals of 4% PDFF for a 0 – 12% PDFF range at 23ºC in milk and cream mixtures. The long-term goal is to use this device for in-vivo clinical applications, such as measurement of intra-hepatic and intra-muscular fat.

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