Ultrashort echo time magnetization transfer (UTE-MT) imaging and modeling – magic angle independent biomarkers of tissue properties
Yajun Ma1, Hongda Shao1, Michael Carl2, Eric Chang1, and Jiang Du1
1Department of Radiology, UCSD, San Diego, CA, United States, 2Global MR Application & Workflow, General Electric, San Diego, CA, United States
Magnetic resonance
imaging biomarkers such as T2 and T1rho have been widely used in the evaluation
of osteoarthritis (OA). The principal confounding factor for T2 and T1rho measures
is the magic angle effect, which may result in a several fold increase in T2
and T1rho values when the fibers are oriented near 55° (the magic angle)
relative to the B0 field. This often far exceeds the changes produced by OA,
and may make definitive interpretation of elevated T1rho and T2 values difficult or impossible. Magic angle independent MR biomarkers are
highly desirable for more accurate assessment of OA. In this study we report the use of two-dimensional
ultrashort echo time magnetization transfer (UTE-MT) imaging and modeling for
magic angle independent assessment of the tissue
properties.
This abstract and the presentation materials are available to members only;
a login is required.
