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Abstract #2273

Elevated adiabatic $$$T_{1\rho}$$$ and $$$T_{2\rho}$$$ in articular cartilage are associated with symptoms and structural changes in early osteoarthritis

Victor Casula1,2, Mikko J. Nissi3,4, Jana Podlipsk√°1,5, Marianne Haapea6,7, Simo Saarakkala1,2,7, Ali Guermazi8, Eveliina Lammentausta2,7, and Miika T. Nieminen1,2,7

1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 3Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 4Diagnostic Imaging Center, Kuopio University Hospital, Kuopio, Finland, 5Infotech Oulu, University of Oulu, Oulu, Finland, 6Department of Psychiatry, Oulu University Hospital, Oulu, Finland, 7Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, 8Department of Radiology, Boston University School of Medicine, Boston, MA, United States

Adiabatic $$$T_{1\rho}$$$, adiabatic $$$T_{2\rho}$$$ and $$$T_2$$$ of articular cartilage (AC) were compared between patients with pre- or early radiographic knee osteoarthritis (OA) (KL=1,2) and volunteers. Further comparisons were performed after classifying the subjects according to different signs of OA, including symptoms and functional impairment assessed by the Western Ontario and McMaster Universities questionnaire (WOMAC) and presence of structural changes assessed by MRI OA Knee Score (MOAKS). Increased adiabatic $$$T_{1\rho}$$$ and $$$T_{2\rho}$$$ were significantly associated with clinical signs of OA. The findings suggest that novel rotating frame of reference techniques have considerable potential for in vivo OA research and clinical use.

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