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Abstract #2313

Combining Multi-therapy in Singlet Vehicle

Yuqi Yang1, Shizhen Chen1, Sha Li1, Lianhua Liu1, and Xin Zhou1

1Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China, People's Republic of

Two types of water-insoluble texphyrins (TP), anticancer drug Gd-TP and photosensitizer Lu-TP, were synthesized and loaded onto RGD-functionalized graphene quantum dots (GQDs) via π-π stacking. The obtained complex could be used as a MRI-fluorecent imaging multi-model probe for cancer therapy. Compared with conventional photodynamic therapy (PDT), our method demonstrated better therapy efficiency for deeper tissue, because a laser with longer wavelength was applied to active the photosensitizer Lu-TP. Furthermore, reactive oxygen species resulted from the reaction between redox active drug Gd-TP and cellular reducing metabolites and photothermal effect from GQDs led cancer cells more impressionable to PDT from Lu-TP.

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