1Internal Medicine II, University Hospital of Ulm, Ulm, Germany, 2Small Animal MRI, University of Ulm, Ulm, Germany, 3Inorganic Chemistry II, University of Ulm, Ulm, Germany
Quantification of 1H
MR contrast agents (CA) is limited by the only indirect visualization of the changes
of the relaxation properties of the surrounding tissue. Using alternative
nuclei such as fluorine (19F) as CA enables direct and quantifiable
readout of local CA aggregations, since the 19F signal linearly
correlates with its local concentration. However non-uniformity of the
transmit/receive radiofrequency fields impact the resulting absolute signal,
leading to wrong quantification results. Application of an easy-to-use time-efficient
B1+/B1--mapping technique for
correction of the 19F signal in vivo is presented in this
work.
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