Development of Calibrationless Parallel Imaging Methods for Clinical Hyperpolarized Carbon-13 MRI Studies
Yesu Feng1, Jeremy Gordon1, Peter Shin1, Cornelius von Morze1, Michael Lustig2, Peder E.Z. Larson1, Michael A. Ohliger1, Lucas Carvajal1, James Tropp3, John M Pauly4, and Daniel B. Vigneron1
1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2EECS, UC Berkeley, Berkeley, CA, United States, 3GE Healthcare, Fremont, CA, United States, 4Electrical Engineering, Stanford, Stanford, CA, United States
Hyperpolarized
(HP) 13C imaging requires fast data acquisition due to the fast T1
relaxation. Parallel imaging methods are well suited for acceleration of data
acquisition, yet conventional parallel imaging schemes require explicit calibration
of coil sensitivity which presents significant challenge to HP 13C
imaging. In this study, a calibrationless parallel imaging method was tested
and applied to HP 13C MRI. A 2-fold acceleration was achieved when this
technique was applied together with a 2D EPI readout. This strategy is being
extended for 3D HP 13C EPI for improved volumetric coverage and
better temporal resolution for future clinical studies.
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