Elucidation of the downfield spectrum of human brain at 7T using multiple inversion recovery delays and echo times
Nicole D Fichtner1,2, Anke Henning2,3, Niklaus Zoelch2, Chris Boesch1, and Roland Kreis1
1Depts. Radiology and Clinical Research, University of Bern, Bern, Switzerland, 2Institute for Biomedical Engineering, UZH and ETH Zurich, Zurich, Switzerland, 3Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
Characterization of
the full 1H spectrum may allow for better monitoring of pathologies
and metabolism in humans. The downfield part (5-10ppm) is currently less well
characterized than upfield; this work aims to benefit from higher field
strength in order to quantify T1 and T2 in the downfield
spectrum in human grey matter at 7T. We fitted downfield spectra to a heuristic
model and obtained relaxation times for twelve peaks of interest. The T1’s
are higher than those at 3T downfield; peaks with lower T1’s may
include macromolecules. The T2’s are mostly shorter than those
reported for upfield peaks at 7T.
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