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Abstract #2382

Large Improvements of RF field Transmission Efficiency and Detection Sensitivity for Ultrahigh-field In vivo 31P MRS using Emerging Technology of Ultrahigh Dielectric Constant Material

Byeong-Yeul Lee1, Xiao-Hong Zhu1, Sebastian Rupprecht2, Michael T. Lanagan3, Qing X. Yang2,4, and Wei Chen1

1Center for Magnetic Resonance Research, Radiology, University of Minnesota, Minneapolis, MN, United States, 2Center for NMR Research, Radiology, The Pennsylvania State College of Medicine, Hershey, PA, United States, 3Engineering Science and Mechanics, The Pennsylvania State College of Engineering, University Park, PA, United States, 4Neurosurgery, The Pennsylvania State College of Medicine, Hershey, PA, United States

Compared to 1H MRS, X-nuclei MRS for human application faces two challenges: higher requirement of RF power (thus, higher SAR) for achieving the same RF pulse flip angle due to a relatively lower gyromagnetic ratio, and still limited SNR even at high/ultrahigh field. In this report, we demonstrate that up to 200% SNR gain was achieved with ultra high dielectric constant (uHDC) materials incorporated into the RF volume coil for 31P MRS at 7T. Concomitantly, the RF power optimized for acquiring the spectra was significantly reduced by 200%. Our data demonstrated that incorporating uHDC with RF coil can significantly boost SNR and reduce RF transmission power X-nuclei MRS applications on top of using high field strength magnet that has approached to its technologic limits.

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