Metabolic ratios can increase or decrease sample size requirements and statistical significance in magnetic resonance spectroscopy
Sarah E. Hoch1, Ivan I. Kirov2, and Assaf Tal3
1Radiology, Sheba Medical Center, Ramat-Gan, Israel, 2Radiology, New York University Langone Medical Center, New York, NY, United States, 3Chemical Physics, Weizmann Institute of Science, Rehovot, Israel
Metabolite ratios are often
used to simplify metabolic quantification. It is often implicitly assumed that
they are also statistically favorable when both numerator and denominator
metabolites change in opposing manners. Herein, we show that even for such
cases, both sample size requirements and statistical significance depend non-trivially
on taking the ratio. We conclude that care must be taken when deciding between
ratios and absolute quantification during study design.
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