Jan Weis1, Lina Carlblom1, Lars Johansson1, Olle Korsgren2, and Håkan Ahlström1
1Department of Radiology, Uppsala University, Uppsala, Sweden, 2Department of Immunology, Genetics and Pathology, Uppslala University, Uppsala, Sweden
A 1.5 T clinical scanner was used
for proton MR spectroscopy (1H-MRS) of human pancreas allografts.
The main purpose was to estimate intracellular lipid content in non-adipose
pancreatic cells. The secondary aim was to quantify total fat and
choline-containing compounds. Spectrum
processing was performed in the time domain using MRUI software package. It
was demonstrated that
1H-MRS is an effective method for non-invasive estimation of intracellular
lipid content in non-adipose pancreatic cells. This knowledge could be helpful
in studies of various aspects of β-cell
function (insulin production).