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Abstract #2404

Metabolomic characterization of ovarian tumors by ex vivo magnetic resonance spectroscopy

Feng-Hua Ma1, Jin-Wei Qiang2, Guo-Fu Zhang1, Ya-Min Rao3, Hai-Min Li4, and Song-Qi Cai4

1Department of Radiology, Obstetrics & Gynecology Hospital, Shanghai Medical College,Fudan University., Shanghai, China, People's Republic of, 2Department of Radiology, Jinshan Hospital, Shanghai Medical College,Fudan University, Shanghai, China, People's Republic of, 3Department of Radiology, Obstetrics& Gynecology Hospital, Shanghai Medical College, Fudan University, Shanghai, China, People's Republic of, 4Department of Radiology, Jinshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China, People's Republic of

Coherent results obtained by ex vivo and in vivo measurements allow the translation of biomarker findings from studies of tissue specimens (ex vivo) to those of patients (in vivo), and therefore it is important to establish how well correlated these metabolic profiles are. Such correlation has been evaluated for brain tumors, prostate cancer and cervical cancer, but without comparison of ovarian tumors. In this study we try to investigate the relationship between the Cho/Cr from in vivo MRS and the Cho/TSP of ex vivo MRS from tissue samples and the potential to bridge molecular and imaging diagnostics.

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Abstract